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同位素  2014 

同位素标记敌百虫-甲氧基-D6和敌敌畏-甲氧基-D6的合成

DOI: 10.7538/tws.2014.27.01.0008, PP. 8-14

Keywords: 同位素标记,合成,敌百虫,敌敌畏,表征

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Abstract:

以CD3OD为同位素源,经与三氯化磷酯化得到亚磷酸二甲酯,再进一步与三氯乙醛加成得到敌百虫-甲氧基-D6,碱解脱去氯化氢分子,重排后生成敌敌畏-甲氧基-D6。以消耗CD3OD计算稳定同位素标记敌百虫-甲氧基-D6和敌敌畏-甲氧基-D6提纯后总收率分别为57.7%和47.3%。产物经高效液相色谱(HPLC)、质谱(MS)和核磁(NMR)等仪器的鉴定为目标物质,化学纯度大于98.0%,同位素丰度高于98.0%,可作为食品安全领域检测用同位素内标试剂。

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