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同位素  2004 

CD20阳性B细胞NHL~(131)I-美罗华放射免疫治疗剂量个体化的临床初步研究

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Keywords: 131I-美罗华,放免治疗,CD20阳性B细胞,剂量个体化

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Abstract:

本研究旨在观察不同个体间131I-美罗华全身清除速率的差异,并拟定131I-美罗华放射免疫治疗个体化治疗剂量。选取CD20阳性B细胞NHL患者13例,于不同时相行全身平面显像,监测131I-美罗华的全身分布和清除情况,绘制时间-放射性曲线得到全身清除速率常数(λ),计算全身有效半清除时间Teff,采用医用内照射吸收剂量(MedicalInternalRadiationDosimetry,MIRD)法求得示踪剂量水平的全身辐射吸收剂量,并参照体重为70kg的标准人体模型131I-美罗华全身最大耐受剂量为75cGy,求得个体化的最大允许注射活度。结果显示13例患者Teff为58.73~177.69h(96.87±30.58h),似呈正态分布;最大允许注射活度为1.14~2.95GBq,其分布无明显规律。根据求得的最大允许注射活度试行治疗其中1例病人,其病情获得了部分缓解。

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