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同位素  1999 

~(99)Tc~m-抗纤维蛋白单克隆抗体对兔动静脉血栓的放免显像

, PP. 155-155

Keywords: ~(99)Tc~m标记,单克隆抗体SZ-63(McAbSZ-63),血栓,纤维蛋白,放射免疫显像

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Abstract:

以亚氨基噻吩盐酸盐(2IT)法修饰抗纤维蛋白的单克隆抗体(McAb)SZ63,采用99Tcm标记葡庚糖酸钠(GH)配体交换法标记。制备实验性兔股动脉和股静脉血栓模型后,经耳缘静脉注入99TcmSZ63进行SPECT显像。99Tcm标记非特异性鼠IgG作为阴性对照。显像结果表明,兔陈旧血栓显像清晰,其最佳显像时间为注射99TcmSZ63后2~4h;99Tcm标记非特异性IgG,未见血栓显像。因此99TcmSZ63具有活体内血栓定位导向能力,显像时间短,用于血栓性疾病的放免显像有一定的可行性。

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