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同位素  2000 

~(188)Re-EDTMP的制备及其小鼠体内分布

, PP. 157-157

Keywords: ~(188)Re-EDTMP,标记条件,体外稳定性,小鼠体内分布

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Abstract:

本工作研究了反应时间、配体含量、亚锡含量、体系pH等条件对188Re标记EDTMP标记率的影响,确定了最佳标记条件。在此条件下,188Re-EDTMP标记率>98%。载体对标记物稳定性影响较大,无载体标记物24h后放化纯度降至91%,而有载体标记物24h后放化纯度>95%。小鼠体内分布表明,188Re-EDTMP有良好的骨吸收,血液清除快,主要经泌尿系统排泄。188Re-EDTMP作为骨转移癌镇痛的放射性药物有进一步研究的价值。

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