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同位素  2003 

核医学显像活体示踪干细胞

, PP. 226-226

Keywords: 核医学,干细胞,移植,示踪

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Abstract:

干细胞移植后,活体追踪干细胞对实验研究和指导临床应用都有重要意义。将细胞内多种内源性分子作为靶,利用放射性核素标记相应的配基进行显像的核医学显像技术具有特异性强、灵敏度高等特点,成为移植后在体追踪干细胞最具潜力的手段。分析各种核医学显像近年来的发展和部分干细胞研究结果,发现在各种核医学显像方法中,受体显像方法简便,最有可能首先进入干细胞示踪领域,但其稳定性和通用性较低;而利用寡聚核苷酸为探针的反义显像特异性高、通用性好,将成为干细胞活体示踪的有效途径。

References

[1]  Dougan H,Weitz JI,Stafford AR,et al.Evaluation of DNA Aptamers Directed to Thrombin as Potential Thrombus Imaging Agents [J].Nucl Med Biol,2003,30:61-72.
[2]  Armuzzi A,Marcoccia S,Zocco MA,et al.Non-invasive Assessment of Human Hepatic Mitochon-drial Function Through the 13C-methionine Breath Test[J].Scand J Gastroenterol,2000,35(6) :650-653.
[3]  Tavitian B,Terrazzino S,Kuhnast B,et al.In Vivo Imaging of Oligonucleotides With Positron Emission Tomography [J].Nat Med,1998,4:467-471.
[4]  Ishii T,Furube M,Hirano S,et al.Evalutation of 13C-phenylalanine and 13C-tyrosine Breath Tests for the Measurement of Hepatocyte Functional Capacity in Patients With Liver Cirrhosis [J]. Chem Pharm Bull (Tokyo),2001,49(12) :1507~1511.
[5]  Wutzke KD,Radke M,Breuel K,et al.Triglyc-eride Oxidation in Cystic Fibrosis:a Comparison Between Different 13C-labeled Tracer Substances [J].J Pediatr Gastroenterol Nutr,1999,29,148~154.
[6]  王世真.核技术在药物研究中的应用[M].北京:中国协和医科大学出版社,2001.
[7]  Lam TK,Leung DT.More on Simplified Calculation of Body-surface Area [J].N Engl J Med,1988,318(17) :1130.
[8]  Kornblum HI,Geschwind DH.Molecular Markers in CNS Stem Cell Research:Hitting a Moving Target [J].Nat Rev Neurosci,2001,2:843-846.
[9]  Gehan EA,George SL.Estimation of Human Body Surface Area From Height and Weight[J].Cancer Chemother Rep,1970,54(4) :225~235.
[10]  Hermann T,Patel DJ.Adaptive Recognition by Nucleic Acid Aptamers [J].Science,2000,287:820-825.
[11]  Haycock GB,Schwartz GJ,Wisotsky DH.Geometric Method for Measuring Body Surface Area:a Height Weight Formula Validated in Infants,Children and Adults[J].The Journal of Pediatrics,1978,93(1) :62~66.

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