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系列樟脑型β-二酮化合物的合成

Keywords: D(+)-樟脑,合成,樟脑型β-二酮

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Abstract:

樟脑由于具有较大的空间位阻,其α位的亚甲基较直链α位碳难活化.从D(+)-樟脑出发,采用高沸点的乙二醇二乙醚做溶剂,氢化钠作碱催化剂,合成了3-苯甲酰基樟脑,3-乙酰基樟脑和3-三氟乙酰基樟脑等系列樟脑型β-二羰基化合物,产率为30%58.3%.目标产物用1HNMR,质谱(MS)来表征.并讨论了溶剂,碱催化剂以及提纯方法对反应的影响.

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