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一种大环多胺铜配合物的DNA切割活性研究

, PP. 111-114

Keywords: 西佛碱,大环多胺,DNA,氧化切割

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Abstract:

研究了一种西佛碱型大环多胺铜配合物对DNA的切割活性及切割机理.凝胶电泳实验结果表明,不加入任何还原剂时,该配合物对pBR322DNA具有良好的切割活性.机理实验表明切割方式可能为主要以单线态氧参与,并伴随有羟基自由基和超氧阴离子的氧化断裂.

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