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肝细胞癌中EZH2和AFP的表达及临床意义

, PP. 1089-1092

Keywords: 肝细胞癌,肝细胞癌,EZH2,甲胎蛋白

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Abstract:

目的探讨Zeste基因增强子同源物2(enhancerofzestehomolog2,EZH2)和甲胎蛋白(alphafetalprotein,AFP)在肝细胞癌(HCC)中的表达及其临床意义。方法采用HE染色和免疫组化法检测EZH2和AFP在96例肝细胞癌组织及其癌旁组织的表达情况及其与临床病理因素的关系。结果HCC组织中EZH2和AFP表达高于癌旁组织(P0.05)。AFP在伴有脉管浸润的病例中的阳性表达率(57.7%)高于无脉管浸润者(27.3%)(P0.05)。EZH2和AFP阳性表达率均在低分化HCC组织中高于高分化HCC(P0.05)。结论EZH2和AFP的联合检测,对于评估HCC浸润、转移具有一定临床意义。

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