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胰岛素样生长因子-2在胶质瘤中表达的意义

Keywords: 胰岛素生长因子-2,胶质瘤,高级别,低级别

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Abstract:

目的探究胰岛素样生长因子-2(IGF2)在胶质瘤中表达的意义。方法运用HE染色、免疫组化、FQ-RT-PCR的实验方法,检测不同级别胶质瘤中IGF2的表达水平。结果HE染色示高、低级别胶质瘤组织在细胞排列形式及细胞形态上存在差异;免疫组化示IGF2在高、低级别胶质瘤组织中均有表达,且高级别组高于低级别组(P<0.05);FQ-RT-PCR可见IGF2的相对表达量在高级别组(1.19±1.40)高于低级别组(0.06±0.02)(P<0.05)。结论IGF2的表达随着胶质瘤病理级别的增高而增加,在胶质瘤的发生发展中发挥一定作用。

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