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益赛普与柳氮磺胺吡啶治疗强直性脊柱炎的Mete分析

, PP. 545-552

Keywords: 益赛普,柳氮磺胺吡啶,强直性脊柱炎,Mete分析

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Abstract:

目的评价益赛普与柳氮磺胺吡啶治疗强直性脊柱炎的疗效和副作用。方法计算机检索CochraneLibrary(2013年第3期),MEDLINE(1966~2013.10),EMbase(1974~2013.10),中国生物医学文献数据库(1978~2013.10),中国期刊全文数据库(1994~2013.10),中文科技期刊全文数据库(1989~2013.10),万方数据库(1980~2013.10)中所有益赛普与柳氮磺胺吡啶治疗强直性脊柱炎的随机对照试验和半随机对照试验。由两名评价员独立提取资料,并对其方法学质量进行评价。对符合纳入标准的研究用RevMan5.2软件进行Meta分析。结果共纳入7个研究940例患者,Meta分析结果示益赛普较柳氮磺胺吡啶治疗强直性脊柱炎患者能有效提高达到ASA20的病例数OR=2.71,95%CI(2.22,3.32),改善治疗终点时Bath强直性脊柱炎测量指数(BASMI)MD=-0.43,95%CI(-0.46,-0.40),提高脊柱活动度(Schober试验)MD=0.54,95%CI(0.04,1.03),降低红细胞沉降率MD=-6.23,95%CI(-7.83,-4.63),降低C-反应蛋白MD=-5.12,95%CI(-6.79,-3.45)。在骶髂关节MRI炎症评分两药间差异无统计学意义MD=-0.26,95%CI(-0.76,0.24)。两种药物用药期间发生呼吸道感染事件差异无统计学意义OR=1.33,95%CI(0.26,6.85),发生胃肠道反应事件差异有统计学意义OR=0.33,95%CI(0.12,0.89)。结论益赛普较柳氮磺胺吡啶在改善患者功能,降低红细胞沉降率,炎症反应蛋白更有效,而且发生胃肠道反应的事件更少。

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