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多囊卵巢综合征患者卵泡液中胰岛素样生长因子Ⅰ的表达

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Keywords: 多囊卵巢综合征,卵泡液,体外受精-胚胎移植,胰岛素样生长因子Ⅰ

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Abstract:

目的测定多囊卵巢综合征(polycysticovarysyndrome,PCOS)患者取卵日卵泡液中胰岛素样生长因子Ⅰ(insulinlikegrowthfactorⅠ,IGF-Ⅰ),雌二醇(estradiol,E2)及睾酮(testosterone,T)浓度的表达,探讨其在PCOS发病过程中可能的作用机制。方法对体外受精-胚胎移植(IVF-ET)助孕的PCOS患者(50例)和非PCOS患者(52例)的卵泡液进行IGF-I、E2、T水平测定并分析其表达水平的差异。结果PCOS患者卵泡液IGF-I、E2、T的水平均高于非PCOS患者(P<0.05)。PCOS患者与非PCOS患者卵泡液中IGF-I水平与E2、T的水平均呈正相关(P<0.01或P<0.05)。结论IGF-I作为卵巢内局部重要的自分泌-旁分泌调节因子,可能参与了PCOS的发病过程。

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