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大鼠岛叶和杏仁核点燃癫痫模型相关性的研究

, PP. 460-462

Keywords: 杏仁核,岛叶,癫痫发作,大鼠,点燃模型

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Abstract:

目的探讨岛叶与杏仁核在癫痫发作中的相互关系。方法建立杏仁核和岛叶电刺激点燃癫痫发作模型,分别将普鲁卡因显微注射入大鼠岛叶或杏仁核,电刺激杏仁核或岛叶,观察不同位点注射普鲁卡因对不同点燃模型癫痫发作的影响。结果普鲁卡因注射入杏仁核显著抑制大鼠岛叶点燃癫痫发作,而注射入岛叶也显著抑制大鼠杏仁核点燃癫痫发作;被抑制的大鼠,增高刺激强度能诱导出现癫痫大发作,发作形式及癫痫大发作持续时间与对照组相似。结论在同侧杏仁核和岛叶可理解为一“灶性复合体”,刺激杏仁核同时激活同侧岛叶;杏仁核也是岛叶皮质被点燃引发癫痫发作的一个整体的和必要的结构。

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