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晚发系统性红斑狼疮102例临床分析

, PP. 183-185

Keywords: 系统性红斑狼疮,晚发,临床特征

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Abstract:

目的探讨晚发系统性红斑狼疮(SLE)的临床特征。方法收集晚发SLE(发病年龄≥50岁)102例和同期早发SLE(发病年龄<50岁)415例患者资料,比较分析两组的临床表现、实验室指标。结果晚发SLE占所有SLE患者的19?7%。其中女∶男为5?38∶1,明显低于早发组(女∶男为11?2∶1),差异有统计学意义(?P?<0?01)。晚发组发病到确诊的平均时间长,疲乏、关节痛、体重下降、肌痛肌无力、肺部病变发生率高,肾损害、雷诺现象、脱发的发生率低(?P?<0?05),血沉增快、肝功能损害检出率高,而补体(C?3C?4)降低、白蛋白降低、dsDNA阳性检出率低(?P?<0?05)。结论晚发SLE在临床表现及实验室检查等方面不典型,在临床诊治中应给予足够重视。

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