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载脂蛋白B基因EcoRⅠ和MspⅠ多态性与颈动脉粥样硬化的关系

, PP. 157-160

Keywords: 颈动脉粥样硬化,多态性,载脂蛋白B,基因

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Abstract:

目的探讨载脂蛋白B(apoB)基因EcoRI和MspI位点多态性与颈As、血脂代谢的关系。方法用二维超声测量97例颈As患者和68例健康者IMT及PI,PCR-RFLP技术检测apoB基因EcoRI、MspI多态性。结果(1)颈As组和对照组R?-等位基因频率比较差异无统计学意义,但R?-R?-/R?+R?-基因型TG、TC、LDL-C、apoB显著高于R?+R?+基因型;(2)颈As组和对照组M?-等位基因频率比较差异无统计学意义,M?-M?-/M?+M?-和M?+M?+基因型间TG、TC、LDL-C、HDL-C、apoB、apoAI等比较差异无统计学意义。结论(1)ApoB基因EcoRI位点多态性与血脂代谢有明显关系,与颈As程度关系不明显。(2)ApoB基因MspI位点多态性与血脂代谢和颈As程度无明显关系。

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