Huiming J in，QinhangL，Xiang C，et al？Dysfunction of microvascular endo thelial cells induced by necrosis factor(TNFα)：cellular and molecular mechanism[J].C lin Hemorheol & Microcire,2000，23：109-112？？
[3]
Zetter BR？The endothelial cells of large and small blood vessels[J].D iabetes，1981，30(Suppl 2)：24-28？？
[4]
Glogowshi EA，Tsiani E，Zhou X，et al，High glucose alters the response o f me sanial cell protein kinase C isoforms to ensothlin[J].Kidney Int，1999，55：48 6-499？？
[5]
Ha H，Kin KH？Pathogenesis of diabetic nephropathy：the role of oxidative stress and protein kinase C[J].Diabetes Res Clin Praet，1999，45：147-151？ ？
[6]
Fooree T，Bonventre J？Growth factors and mitogen activated protein kinas e[J].Hypertention，1998，31：152-161？？
[7]
Sugken P，Clerk A？Stress responsive mitogen activated protein kinase in myocardium[J].Circ Res，1998，83：345-352？？
[8]
Tomlinson DR？Mitogen actiyated Protein kinases as glucose transdu cers for diabetic complications[J].Diabetdogia，1999，42：1271-1281？？
[9]
Haneda M，Koya D，Kikkawa R？Cellular mechanisms in the development and pro gression of diabetic nephropathy：activation of the DAG-PKC-ERK pathway[J]. A m J Kidney Dis，2001，38(4 Suppl 1)：S178-181？？
Treins C，Giorgetii-Peraldi S，Murdaca J，et al？ Regulation of vascul arend othelial growth factor expression by advanced glycation end products[J]. J Bi ol Chem，2001，276(47)：43836-43841？？
[12]
Suzuki M，Akimoto K，Hattori Y？Glucose upregulates plasminogen activat or i nhibitor-I gene expression in vascular smooth muscle cells[J]. Life Sci，2002 ，72(1)：59-66？？
[13]
Chen YB，Budd RC，Kelm RJ，et al？Augmentation of Proliferation of Vas cular Smooth Muscle Cells by Plasminogen Activator Inhibitor Type 1[J]．Arterioscle r Thromb Vasc Biol，2006，26(8)：1777-1783
[14]
刘声远？糖尿病血管病变机制与防治进展[J].微循环学杂志，2006，16(4 )：3-6？？
[15]
Natarajan R，Scott S，Bai W，et al？Angiotensin Ⅱsignaling in VSMC under high glucose conditions[J].Hypertension，1999，33：378-384？〖ZK)〗？
