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β-氨基丙腈抑制赖氨酰氧化酶对小鼠免疫功能的影响

, PP. 137-139

Keywords: 赖氨酰氧化酶,β-氨基丙腈,免疫功能,小鼠

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Abstract:

目的观察β-氨基丙腈(β-Aminopropionitrile,BAPN)抑制赖氨酰氧化酶(lysyloxidase,LOX)后小鼠免疫功能的变化。方法选用18~22g的正常ICR小鼠,以β-氨基丙腈100mg/kg连续灌胃10d。处死后检测小鼠胸腺重、脾重、巨噬细胞吞噬功能;采用绵羊红细胞作为抗原,检测小鼠抗体生成细胞功能;采用MTT法检测小鼠脾淋巴细胞对ConA刺激的转化能力。结果以β-氨基丙腈抑制LOX活性,明显降低小鼠胸腺/体重比值;巨噬细胞吞噬率及吞噬指数均下降;小鼠抗体生成细胞数减少;ConA诱导的小鼠脾淋巴细胞增殖能力减弱。HTXK结论β-氨基丙腈抑制赖氨酰氧化酶可减弱小鼠免疫功能。

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