全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

乌司他丁对体外循环下瓣膜置换术患者 TNF-α、MDA、PMN的影响

, PP. 494-497

Keywords: 体外循环,TNF-α,肺保护,乌司他丁,心脏瓣膜置换

Full-Text   Cite this paper   Add to My Lib

Abstract:

目的观察体外循环(cardiopulmonarybypass,CPB)下瓣膜置换围术期应用乌司他丁药物对肺保护作用。方法选择30例择期行心脏瓣膜置换术的患者随机分为乌司他丁组和对照组,每组15例。乌司他丁组给予乌司他丁12000IU?kg-1于切皮后至CPB前缓慢静注半量,另半量加入预充液中随转机进入体内;对照组给予等量0.9%氯化钠注射液,用法同乌司他丁组。两组分别麻醉诱导后即切皮前(T1)、体外循环45min时(T2)、体外循环停机前5min(T3)、停机后6h(T4)及停机后24h(T5)5个时间点,T1~T3时间点即刻送动脉血检测中性粒细胞(PMN)值;分离血清检测T1~T3时点丙二醛(MDA)浓度和T1~T5时点TNF-α浓度。结果两组CPB开始后血清TNF-α、MDA、PMN浓度逐渐升高,CPB停机前5min三者血清浓度达到高峰,CPB后24hTNF-α仍维持在很高的水平;乌司他丁组T3~T5时点的血清TNF-α浓度及T2~T3时点的血清MDA浓度、PMN值低于对照组相同时点值,差异有统计学意义(P<0.05)。结论乌司他丁可降低体外循环心脏瓣膜置换术CPB期间血液PMN及血清TNF-α、MDA的表达,起到肺保护的作用。

References

[1]  Sievers H, Freund K, Eleflheriadis S, et al.Lung protection during total cardio puhnonary bypass by isolated lung perfusion:results of anovel perfusion Strategy[J].Ann Thorar Surg,2003,76(2):516.
[2]  Calvin S,Song W,Anthom P,et a1.Pulnmnary dysfunction after cardiac surgery[J].Chest,2002,121(4):1269.
[3]  Ambrosinig, Adidac, Altieridc. A novel and-apop tosis gene,survivin.Expressed in cancer and Lymphoma[J].Natmed,1997,3(8):917-921.
[4]  Sievers H,Freund K,Eleflheriadis S,et al. Lung protection during total cardiopuhnonary bypass by isolated lung perfusion:results of a novel perfusion strategy[J].Ann Thorar Surg,2003,76(2):5l6.
[5]  Finn AB, Morgan P. Effects of inhitbition of complementactivation using soluble complement receptor on neutrophil CD11/CD18 and L-selection expression and release of IL-8 and elastase in simulated cardiopulmonary bypass[J]. Thorac Cardiovasc Surg,1996,111:451-459.
[6]  Friedman M, Warg SY, Sellke FW, et al.Neutrophil adhesion blockade with NPC decrease pulmonary injury after total cardiopulmonary bypass[J]. Thorac Cardiovasc Surg,1999,111:460-468.
[7]  Lif,Altieridc. The cancer anti-apoptosis mouse surviving gene; characerization of Locus and transcriptional requirements of basal and cell-dependent expression[J].Cancer Res,1999,59(13):3143-3151.
[8]  Lacasseec,Bairds,Kdrnelukrg,et al.The inhibitors of apoptosis(IAPs)and their emerging role in cancer[J].Oncogene,1998,17(25):3247-3259.
[9]  Hirotaka,Isober,Kenji okajima,et al.Inhibition of tumor necrosis factorproduction by urinary trypsin inbibitor[J].International Congress Series, 2003(1225):69-74.
[10]  应斌宇,孙来芳.乌司他丁对创伤弧菌脓毒血症实验大鼠细胞因子的影响和意义[J].实用医学杂志,2004,20(4):362-364.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133