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肝硬化患者外周血TLR、CD14表达及其与内毒素血症的关系

, PP. 63-65

Keywords: 肝硬化,内毒素血症,Toll样受体

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Abstract:

目的探讨肝硬化患者外周血单个核细胞(PBMC)表面CD14、TOLL样受体(TLR2、TLR4)的表达情况及其与内毒素血症的关系。方法分别采用显色基质鲎试剂试管法和流式细胞术检测50例肝硬化患者和30例健康志愿者外周血内毒素浓度及PBMC表面CD14、TLR2、TLR4的表达。结果肝硬化患者外周血内毒素浓度及PBMC表面CD14、TLR2、TLR4的表达高于正常对照组(?P?<0?05);肝硬化合并腹水患者外周血内毒素浓度及PBMC表面CD14、TLR2、TLR4的表达高于肝硬化无腹水患者(?P?<0?05);肝硬化患者外周血内毒素浓度与PBMC表面CD14、TLR2、TLR4的表达呈正相关(?P?<0?05)。结论肝硬化患者外周血内毒素浓度及PBMC表面CD14、TLR2、TLR4的表达均高于正常人,内毒素及内毒素受体CD14、TLR2、TLR4协同作用介导机体炎症反应,可能导致肝硬化患者病情进一步加重。

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