Park WS,Cho YG,Kim CJ,et al?Hypermethylation of the RUNX3 gene in hepatocellular carcinoma[J].Exp Mol Med,2005,37(4):276-281??
[5]
Brueckner B,Kuck D,Lyko F?DNA methyltransferase inhibitors for cancer therapy[J].Cancer Journal,2007,13(1):17-22?〖ZK)〗?
[6]
Mori T,Nomoto S,Koshikawa K,et al?Decreased expression and freq uent all elic inactivation of the RUNX3 gene at 1p36 in human hepatocellular carcinoma[J ].Liver Int,2005,25(2):380-388??
[7]
Issa JP,Vertino PM,Wu J,et al?Increased cytosine DNA methyltransfe rase activity during colon cancer progression[J].Natl Cance RInst,1993,85(15 ) :1235-1240??
[8]
Li QL,Ito K,Sakaura C,et al?Causal relationship between the loss of RUNX3 expression and gastric cancer[J].Cell,2002,109:113-124??
[9]
Fang W,Piao Z,Simon D,et al?Mapping of a minimal deleted region in huma n hepatocellular carcinoma to 1p36?13-p36?33 and mutational analysis of the RI Z(PRDM2)gene localized to the region?Gene Chromosomes Cancer[J].2000,28:2 69-275??
[10]
[ZK(#]Brown KD,Robertson KD?DNMT1 knockout delivers a strong blow to g enome stability and cell viability[J].Nat Genet,2007,39(3):289-290??
Saito Y,Kanai Y,Nakagawa T,et al?Increased protein expression of D NA methyltransferase(DNMT)1 is significantly correlated with the malignant potenti al and poor prognosis of human hepatocellular carcinomas[J].Int J Cancer,2 003,105:527-532??
[13]
Nomoto S,Kinoshita T,Kato K,et al?Hypermet hylation of multiple ge nes as clonal markers in multicentric hepatocellular carcinoma[J].Br J Cancer ,2007,97(9):1260-1265