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宁夏汉族Graves病与CYP27B1基因 启动子-1260C/A多态性相关性研究

, PP. 540-542

Keywords: Graves病,CYP27B1基因,基因多态性

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Abstract:

目的探讨CYP27B1(CytochromoP450CYP)基因启动子C-1260A位点多态性与宁夏汉族Graves病(GD)的相关性。方法采用聚合酶链反应-限制性片段长度多态性(polymerasechainreactionrestrictionfragmentlengthpolymorphism,PCR-RFLP)技术,分析汉族GD99例和正常对照83例CYP27B1基因启动子-1260C/A多态性。结果宁夏汉族CYP27B1基因-1260C/A检出GD组与对照组的基因型频率分别为37.37%、53.54%、9.09%和43.37%、40.96%、15.66%,两组差异无统计学意义(χ2=4.19,P>0.05);等位基因频率为64.16%、35.86%和63.86%、43.14%,两组差异无统计学意义(χ2=0.00,P>0.05)。结论CYP27B1基因1260C/A的与宁夏地区汉族GD无相关性。

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