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宁夏回、汉族群体IL-6启动子区基因多态性研究

, PP. 449-454

Keywords: 白细胞介素6,基因多态性,回族,汉族

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Abstract:

目的探讨白细胞介素6(interleukin6,IL-6)基因多态性在宁夏回、汉族人群中的分布特征。方法应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法,对210例回族和308例汉族人群白细胞介素6基因启动子区三个多态性位点(-572G/C、-597G/A、-174G/C)进行检测。结果宁夏回族群体IL-6基因三个SNP各基因型频率及等位基因频率分别为,-572G/C(CC55.71%;CG34.76%;GG9.52%;C73.10%;G26.90%);-597G/A(GG94.29%;GA5.71%;AA0%;G97.14%;A2.86);-174G/C(GG96.67%;GC3.23%;CC0%;G98.33%;C1.67%)。宁夏汉族群体IL-6基因三个SNP各基因型频率及等位基因频率分别为,-572(CC52.92%;CG35.71%;GG11.36%;C70.78%;G29.22%);-597(GG92.86%;GA7.14%;AA0%;G96.13%;A3.57);-174(GG97.08%;GC2.92%;CC0%;G98.54%;C1.46%)。两组间差异均无统计学意义(P>0.05);按性别分组,三个SNP位点的基因型频率及等位基因频率差异亦无统计学意义(P>0.05)。结论IL-6基因-572、-597、-174三个多态性位点在宁夏回、汉族人群及不同性别间差异无统计学意义。

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