全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

心绞痛患者PAF、GMP140和TXB2检测的临床意义

, PP. 884-886

Keywords: 心绞痛,血小板活化因子,血小板а-颗粒膜蛋白,血栓烷B2

Full-Text   Cite this paper   Add to My Lib

Abstract:

目的探讨稳定型和不稳定型心绞痛患者血小板的活性状态。方法检测40例稳定型心绞痛患者和62例不稳定型心绞痛患者血清中血小板活化因子(PAF)、血小板а-颗粒膜蛋白(GMP140)及血栓烷B2(TXB2)水平,并与正常对照组30例进行对比分析。结果两组心绞痛患者血清PAF、GMP140及TXB2水平显著高于正常对照组(P<0.05),且不稳定型心绞痛组高于稳定型心绞痛组,不稳定型心绞痛危险分层越高,升高越显著,差异均有统计学意义(P<0.05)。结论心绞痛患者血小板活性升高,其中不稳定型心绞痛患者血小板活性升高更为显著,血小板活性状态与不稳定型心绞痛的危险分层相关。

References

[1]  Kalyanasundaram A, Berger PB. Routine platelet testing should not be performed on all patients undergoing percutaneous coronary intervention[J]. Circ Cardiovasc Interv, 2010, 3(3):284-287.
[2]  Carter AM. Inflammation, thrombosis and acute coronary syndromes[J]. Diab Vasc Dis Res, 2005, 2(3): 113-121.
[3]  Kim HA, Seo KH, Kang YR. Mechanisms of platelet-activating factor-induced enhancement of VEGF expression[J]. Cell Physiol Biochem, 2011,27(1):55-62.
[4]  Koda M, Banno Y, Naganawa T. Effect of neutrophil adhesion on the size of aggregates formed by agonist-activated platelets[J]. Platelets, 2005, 16(18):482-491.
[5]  Kidson-Gerber G, Weaver J, Gemmell R, et al. Serum thromboxane B2 compared to five other platelet function tests for the evaluation of aspirin effect in stable cardiovascular disease[J]. Heart Lung Circ, 2010, 19(4):234-242.
[6]  杨从茂. 急性脑梗死患者血浆GMP-140含量变化及临床意义[J]. 微循环学杂志, 2006,16(4):70.
[7]  Zimmerman GA, Mcintyre TM, Prescott SM, et a1.The platelet activating factor signaling system and its regulators in syndromes of inflammation and thrombosis[J].Crit Care Med, 2002, 30(5Supp1):294-301.
[8]  Louis NA, Hamilton KE, Colsan SP. Lipid mediator networks and leukocyte transmigration[J]. Prostaglandins Leukot Essent Fatty Acids, 2005, 73(3-4):197-202.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133