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VEGF和ERK1/2在不同周龄自发性高血压大鼠肾脏中的表达

, PP. 771-774

Keywords: 自发性高血压大鼠,原发性高血压,血管内皮生长因子,肾脏,细胞外信号调节激酶

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Abstract:

目的研究血管内皮生长因子(VEGF)和细胞外信号调节激酶(ERK1/2)在自发性高血压大鼠(SpontaNeouslyHypertensiveRats,SHR)不同周龄组肾脏中的表达,探讨它们在高血压肾病发生发展中的作用。方法选取4个不同周龄组(4、8、16、20周龄)SHR和正常血压大鼠,将肾脏作常规病理和免疫组化染色,观察肾脏的形态学改变并分析VEGF和ERK1/2在肾脏中的表达。结果SHR从8周龄开始血压升高,随着血压的不断升高,SHR肾小球中VEGF的阳性表达也有所增加,16、20周龄组SHR的表达高于4、8周龄组(P<0.05)。ERK1/2在16、20周龄SHR的肾脏细动脉、小叶间动脉、叶间动脉和弓形动脉中的内皮细胞和血管平滑肌细胞中均有阳性表达,而且阳性细胞数明显多于4周龄SHR(P<0.05)。结论ERK1/2、VEGF可能参与高血压肾脏病变的发生发展过程。

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