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不同剂量异丙酚麻醉对食道癌患者血液流变学的影响

, PP. 293-295

Keywords: 异丙酚,血液流变学,食道肿瘤

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Abstract:

目的评价不同剂量异丙酚麻醉对食道癌患者血液流变学的影响。方法择期行食道癌根治术(开胸)患者30例,ASAI或II级,年龄51~72岁,体重指数≤30kg/m2,随机分为持续泵注异丙酚4mg.(kg.h)-1(A组)、持续泵注异丙酚8mg.(kg.h)-1(B组),每组15例。所有患者于颈内静脉穿刺后麻醉前(T1)、切皮后1h(T2)、2h(T3)、3h(T4)抽取中心静脉血检测血液流变学指标全血黏度(高切、中切、低切)、血浆黏度、红细胞压积、红细胞聚集指数、红细胞刚性指数。结果A组患者全血高、中、低切黏度、血浆粘度以及红细胞聚集指数、红细胞刚性指数在T2、T3、T4均比T1显著降低(P0.05);两组患者红细胞压积各时间点差异无统计学意义(P>0.05)。与B组比较,A组全血?切黏度在T3下降显著(P0.05)。结论术中持续输注4mg.(kg.h)-1异丙酚可以降低食道癌患者的血液黏度。

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