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GSTT1、GSTP1基因多态性与宁夏回族贲门癌遗传易感性研究

, PP. 168-171

Keywords: 贲门癌,GSTT1,GSTP1,多态性

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Abstract:

目的探讨GSTT1、GSTP1基因多态性与宁夏回族贲门癌遗传易感性的关系。方法收集110例贲门癌患者和220例健康个体为对照,以PCR技术检测GSTT1基因缺失,PCR-RFLP(restrictionfragmentlengthpolymorphism)技术检测GSTP1基因105位密码子基因多态。结果GSTT1(-)基因型和GSTP1基因的GG基因型在病例组及对照组之间差异存在统计学意义。同时携带GSTT1(-)、GSTP1*GG基因型的个体在病例组及对照组之间差异存在统计学意义。结论GSTT1(-)基因型及GSTP1*GG基因型是宁夏回族贲门癌发生的危险因素。GSTT1及GSTP1基因105位密码子基因多态在宁夏回族贲门癌的发生过程中存在协同效应,对贲门癌的发病可能起促进作用。

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