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丙戊酸钠和拉莫三嗪对雌性癫痫大鼠血清性激素水平的影响

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Keywords: 丙戊酸钠,拉莫三嗪,癫痫点燃模型,性激素,动情周期

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Abstract:

目的探讨丙戊酸钠(Valproatesodium,VPA)和拉莫三嗪(lamotrigine,LTG)对雌性癫痫大鼠性激素水平的影响。方法28只8周龄SD雌性大鼠随机分为四组正常对照组、模型组、丙戊酸钠组(VPA组)和拉莫三嗪组(LTG组)。模型组、VPA组、LTG组用海人酸(KA)点燃,建立癫痫大鼠模型。建模成功后灌胃法分别予以生理盐水、丙戊酸钠、拉莫三嗪1个月,每3d称重1次,调整给药剂量。灌胃30d后,于动情间期四组大鼠抽取动脉血,电化学发光法测定血清黄体生成素(Luteotropichormone,LH)、卵泡刺激素(Folliestimulatinghormone,FSH)、睾酮(Testosterone,T)、孕酮(Progesterone,P)、雌二醇(Estradiol,E2)浓度,同时取双侧卵巢组织,卵巢称重,行HE染色,运用图像分析软件Image-proPlus6.0进行形态学分析。结果模型组与对照组比较,血清睾酮、黄体生成素水平升高(P0.05);模型组和VPA组大鼠失去正常动情周期;VPA组大鼠体重增加量较其它三组显著增高(P0.05);VPA组与LTG组大鼠激素水平比较,差异有统计学意义(P<0.05)。结论雌性癫痫模型大鼠性激素水平异常,丙戊酸钠较拉莫三嗪易引起雌性癫痫大鼠性激素分泌紊乱。

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