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自然妊娠和辅助生殖技术妊娠孕妇胚胎停育绒毛染色体异常的研究

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Keywords: 荧光原位杂交技术,胚胎停育,染色体数目异常,辅助生殖技术

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Abstract:

目的探讨自然妊娠和辅助生殖技术(ART)妊娠孕妇胚胎停育绒毛染色体异常的差异性。方法选取自然妊娠胚胎停育患者62例、ART妊娠胚胎停育40例,留取绒毛,分别对13、16、18、21、22、X、Y等7种染色体行FISH检测。结果FISH检测102例胚胎停育患者中,异常核型检出共43例,异常率42.16%(43/102);自然妊娠组染色体异常率41.94%(26/62)、ART妊娠组染色体异常率42.50%(17/40),两组差异无统计学意义(P>0.05);高龄妊娠组(≥35岁)染色体异常率高于非高龄妊娠组(0.05)。结论ART不一定增加胚胎染色体异常发生的;高龄妊娠可能增加胚胎染色体异常的发生风险;而染色体异常发生率与胚胎停育次数的增多不相关。

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