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C反应蛋白与代谢综合征的关系

Keywords: C反应蛋白,代谢综合征,农村居民,宁夏

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Abstract:

目的探讨炎症标志物C反应蛋白(C-reactiveprotein,CRP)与宁夏农村居民代谢综合征(MS)的相关关系。方法以2008-2012年参加宁夏农村居民代谢性疾病基线调查并自愿采集空腹静脉血液的550例为研究对象,双抗体夹心ELISA法检测CRP,用统计学方法进行CRP相关因素分析。结果研究样本中226例(41.09%)MS患者,324例非MS患者(58.91%);按代谢指标异常的个数划分为0个代谢指标异常组(血压、血糖、血脂均正常且无中心性肥胖)、1~2个代谢指标异常组、≥3个代谢指标异常组,CRP水平随代谢指标异常数目增加明显升高(P<0.05)。Stepwise逐步回归分析显示,影响CRP浓度的主要因素有腰围、甘油三酯和体重指数,其回归方程为y=-12.985+0.448x1+1.282x2-0.621x3,其中y为CRP(x1为腰围,x2为甘油三酯,x3为体重指数)。结论MS者CRP水平高于无MS者;且随着代谢指标异常数的增加CRP水平逐渐升高,CRP水平升高是发生MS的危险因素。

References

[1]  Ford ES,Giles WH, Mokdad AH,Myers GL. Distribution and correlates of C-reactive protein concentrations among adult US women[J]. Clin Chem, 2004,50(3):574-581.
[2]  Imhof A, Frohlich M, Loewel H,et al. Distributions of C-reactive protein measured by high-sensitivity assays in apparently healthy men and women from different populations in Europe[J].Clin Chem,2003,49(4):669-672.
[3]  Frohlich M, Inthof A,Berg G,et a1.Association between C-reactiveprotein and features of the metabolic syndrome:a population-based study[J].Diabetes Care,2000,23(12):1835-1839.
[4]  陈建华,戴红蕾,方力争.超敏C反应蛋白与MS的相关性研究[J].中华急诊医学杂志,2008,17(3):302-305.
[5]  包玉倩,贾伟平,陈蕾,等.C反应蛋白水平与MS及其组分患病风险的研究[J].中华医学杂志,2006,86(30):2105-2109.
[6]  FIorez H,Castillo-F1orez S,Mendez A,et a1.C-reactive protein is elevated in obese patients with the metabolic syndrome[J].Diabetes Res Clin Pract,2006,71(1):92-100.
[7]  Choi EY, Park EH, Cheong YS,et a1.Association of C-reactive protein with the metabolic risk factors among young and middle-aged Koreans[J].Metabolism,2006,55(3):415-421.
[8]  Cardillo C, Panza JA. Impaired endothelial regulation of vascular tone in patients with systemic arterial hypertension[J].Vasc Med,1998, 3(2):138-144.
[9]  Libby P. Inflammation in atherosclerosis[J]. Nature,2002, 420:868-874.

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