全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

腹腔温热灌注联合全身化疗治疗胃肠道恶性肿瘤临床研究

, PP. 33-36

Keywords: 腹腔温热灌注化疗,全身化疗,胃肠道恶性肿瘤

Full-Text   Cite this paper   Add to My Lib

Abstract:

目的观察腹腔温热灌注(Intraperitonealhyperthermicperfusion,IPHP)联合全身化疗治疗中晚期胃肠道恶性肿瘤的疗效及其不良反应。方法分析162例手术后中晚期胃肠道恶性肿瘤患者资料,其中IPHP联合全身化疗76例(联合组)和全身化疗86例(单纯化疗组),比较两组病人的疗效及其不良反应。结果近期疗效联合组27例Ⅳ期患者中CR6例,PR9例,有效率为55?56%;单纯化疗组34例Ⅳ期患者中CR3例,PR6例,有效率为26?47%(?P<?0?05)。远期疗效3年生存率联合组为77?63%,单纯化疗组为63?95%(?P?>0?05);5年生存率联合组为68?42%,单纯化疗组为37?21%(?P<?0?05)。两组病人不良反应差异无统计学意义。结论腹腔温热灌注联合全身化疗治疗中晚期胃肠道恶性肿瘤的疗效优于单纯全身化疗,不良反应相似,值得临床推广应用。?

References

[1]  Yonemura Y,Bandou E,Kinoshita K,et al?Effective therapy for per itoneal dis semination in gastric cancer[J].Surg Oncol Clin N Am,2003,12(3):635-648??
[2]  Goldberg RM,Hatfield AK,Kahn M,et al?Prospectively randomized North C entral C ancer Treatment Group trial of intensive-course fluorouracil combined with the 1 -isomer of intravenous leucovorin,oral leucovorin,or intravenous leucovorin fo r the treatment of advanced colorectal cancer[J].J Clin Oncol,1997,15(11):33 20-3329??
[3]  李雁,阎晓天,张照兰?胃癌临床治疗新对策[M].北京:中国中医药出版社, 1998:405-412??
[4]  郭向晖,杨立?双路化疗与全身化疗治疗晚期胃癌的疗效观察[J].实用癌症杂 志,2000,15(6):637-639??
[5]  Rothenberg ML,Liu PY,Braly PS,et al?Combined intraperitoneal and intr avenous c hemotherapy for women with optimally debulked ovarian cancer:results from an int ergroup phase II trial[J].J Clin Oncol,2003,21(7):1313-1319??
[6]  Kunisaki C,Shimada H,Nomura M,et al?Lack of efficacy of prophylactic continuou s hyperthermic peritoneal perfusion on subsequent peritoneal recurrence and s u rvival in patients with advanced gastric cancer[J].Surgery,2002,131(5):521-5 28??
[7]  Shen P,Hawksworth J,Lovato J,et al?Cytoreductive surgery and intraper itoneal h yperthermic chemo- therapy with mitomycin C for peritoneal carcinomatosis from n onappendiceal colorectal carcinoma[J].Ann Surg Oncol,2004,11(2):178-186??
[8]  Glehen O,Cotte E,Schreiber V,et al?Intraperitoneal chemohyperthermia and attem pted cytoreductive surgery in patients with peritoneal carcinomatosis of colorec tal origin[J].Br J Surg,2004,91(6):747- 754??
[9]  Beaujard AC,Glehen O,Caillot JL,et al?Intraperitoneal chemohypertherm ia with m itomycin C for digestive tract cancer patients with peritoneal carcinomatosis [J].Cancer,2000,88(11):2512-2519?[ZK)]?
[10]  [ZK(]韩锐,孙燕?新世纪癌的化学预防与药物治疗[M].北京:人民军医出版社, 2005:120-121

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133