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VEGF和MVD在大肠癌组织中的表达及其临床意义

, PP. 17-18

Keywords: 大肠癌,血管内皮生长因子,微血管密度

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Abstract:

目的探讨血管内皮生长因子(VEGF)和微血管密度与大肠癌发展的关系。方法采用免疫组化方法对65例大肠癌、65例癌旁组织及16例正常大肠黏膜组织进行VEGF表达及微血管密度(MVD)测定。结果大肠癌组织中VEGF的表达阳性率明显高于癌旁组织及正常组织(?P<?0?05),与组织学分级无关(?P?>0?05)。VEGF阳性者MVD值显著高于VEGF阴性者(?P<?0?05);大肠癌组织中VEGF的表达水平与MVD呈显著性正相关(?r?s?=0?410,?P?=0?001)。VEGF表达和MVD与大肠癌浸润深度、TNM分期、血行转移密切相关(?P<?0?05)。VEGF表达阳性或高MVD的大肠癌患者预后差(?P<?0?05)。结论VEGF表达与大肠癌血管生成密切相关,VEGF和MVD可作为大肠癌预后检测的指标。

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