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脑源性神经营养因子基因3个SNPs位点 与精神分裂症的相关性

, PP. 953-956

Keywords: 脑源性神经营养因子,精神分裂症,多态性

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Abstract:

目的研究脑源性神经营养因子(Brain-derivedneurotrophicfactor,BDNF)基因启动子区G-712A、外显子区C270T及Val66Met3个SNPs位点与精神分裂症是否存在相关性。方法选取无亲缘关系的精神分裂症患者220例及健康对照组200例提取基因组DNA,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测G-712A、C270T和Val66Met3个多态性位点的基因型,采用HaploView4.0及SPSS11.5软件分析各位点基因型、等位基因频率及组间差异。结果BDNF基因C270T位点的基因型及等位基因频率分布在精神分裂症组与正常对照组差异有统计学意义(P0.05)。结论BDNF基因C270T多态性可能与精神分裂症有关,携带有C270T多态性位点T等位基因的个体可能更容易患精神分裂症。

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