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脂联素水平及其基因+45T/G和+276G/T 与原发性高血压的相关性

, PP. 1019-1022

Keywords: 脂联素,原发性高血压,基因多态性

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Abstract:

目的探讨脂联素(APN)水平及其单核苷酸基因多态性(SNP)+45T/G和+276G/T两个位点与原发性高血压(EH)的相关性。方法238例研究对象分为对照组、原发性高血压组,采用实验-对照研究方法,应用酶联免疫吸附法(ELISA)及聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,对血浆脂联素浓度及脂联素两个位点基因多态性进行检测。结果与对照组相比EH组APN降低(P<0.05);EH组SNP+276T等位基因频率明显升高,多元线性回归分析显示+276基因多态性为EH危险因素。结论EH患者APN水平下降,携带+276T等位基因者患EH的风险增加。

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