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E-Cadherin、β-catenin蛋白在肾透明 细胞癌中的表达及临床意义

, PP. 249-252

Keywords: 肾透明细胞癌,免疫组化,E-Cadherin,β-catenin

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Abstract:

目的探讨E-Cadherin、β-catenin蛋白在肾透明细胞癌(RCCC)组织中的表达及临床意义。方法应用免疫组化方法对62例肾透明细胞癌和10例正常肾组织进行E-Cadherin、β-catenin蛋白检测。结果RCCC组织中,E-Cadherin、β-catenin蛋白异常表达率分别为67.7%(42/62)和77.4%(48/62),二者表达之间具有显著相关性(P<0.01)。E-Cadherin、β-catenin蛋白的异常表达与RCCC病理分级和临床分期呈正相关(P<0.05)。E-Cadherin、β-catenin蛋白的异常表达在侵袭转移组和非侵袭转移组之间差异有统计学意义(P<0.05)。结论E-Cadherin、β-catenin蛋白低表达或异常表达与肾透明细胞癌的分化、恶性程度有关,并对肾透明细胞癌预后评价有一定参考意义。

References

[1]  Bremnes RM,Veve R,Gabrielson E,et al.High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer[J].J Clinoncol,2002,20(10):2417-2428.
[2]  Lioni M,Brafford P,Andl C,Rustgi A,El-Deiry W,Herlyn M,Smalley KS.Dysregulation of claudin-7 leads to loss of E-cadherin expression and the increased invasion of esophageal squamous cell carcinoma cells[J].Am J Pathol,2007,170:709-721.
[3]  Uchikado Y,Natsugoe S,Okumura H,Setoyama T,Matsumoto M,Ishigami S,Aikou T.Slug Expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinoma[J].Clin Cancer Res,2005,11:1174-1180.
[4]  顾国利,魏学明,王石林,等.大肠癌E-cadherin,beta-catenin,MMP-7表达及其临床意义[J].世界华人消化杂志,2007,15:375-380.
[5]  Falkenback D,Nilbert M,Oberg S,Johansson J. Prognostic value of cell adhesion in esophageal adenocarcinomas[J].Dis Esophagus,2008,21:97-102.
[6]  Katagiri A,Watanabe R,Tomita Y.E-cadherin expression in renal cell cancer and its significance in metastasis and survival[J].Br J Cancer,1995,71: 376-379.
[7]  Toru Shimazu,I Jeannette Oosterwijk-Wakka,Hideyuki Akaza et al. Alterations in expression ofcadherin-6 and E-cadherin during kidney development and in renal cell carcinoma[J].Eur Urol,1999,38: 331-338.
[8]  Nouwen EJ,Dauwe S,van der Biest I,De Broe ME.Stage and segment specific expression of cell-adhesion molecules N-CAM,A-CAM,and L-CAM in the kidney[J].Kidney Int,1993,44(1):147-158.
[9]  徐洪涛,王恩华.E钙粘蛋白-环连蛋白复合体与肿瘤[J].国外医学:肿瘤学分册,2004,31(2):107-110.
[10]  ZANG Tong,ZHUANG Liyan,et al.Expression and mutation of beta-catenin in renal cell carcinoma[J].Chin J Surg,2002,38:1.

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