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基于多因子降维法的肺结核易感基因―基因交互作用研究

, PP. 138-140

Keywords: 多因子降维法,基因交互作用,肺结核

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Abstract:

目的分析宁夏银川地区肺结核易感基因间的交互作用。方法结合前期病例对照研究结果(PCR-RFLP法检测肺结核易感基因MCP-1、CCR2、VDR、NRAMP1-3'UTR、NRAMP1D543N、NRAMP1INT4及MBL-G54A分型,银川地区肺结核病例271例,健康对照299例),运用MDR法分析肺结核易感基因―基因交互作用模型。结果有统计学意义的最佳交互模型包含VDR基因和CCR2基因,该模型的检验样本准确度为0.6248,交叉验证一致性的结果为10/10。结论VDR基因和CCR2基因可能协同增强了宿主对结核杆菌的易感性,从而增加了宿主肺结核病的患病风险。

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