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HSP70蛋白在外生殖器鳞状细胞癌的表达及临床意义

Keywords: 外生殖器鳞癌,热休克蛋白70

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Abstract:

目的研究热休克蛋白70(HSP70)在外生殖器鳞癌(External-GenitaliaSquamousCellCarcinoma,EGSCC)的表达及临床意义。方法采用免疫组化技术检测15例正常外生殖器组织、31例EGSCC石蜡包埋组织HSP70蛋白的表达。结果EGSCC组织中HSP70阳性表达率70.9%(22/31),低于正常外生殖器组织中100%的阳性表达率(t'=-7.327,P<0.05),差异有显著性统计学意义。随着疾病的进展,有明显的嗜基底膜细胞染色,HSP70阳性表达与临床分期、组织分化程度无明显相关性。结论HSP70在EGSCC中的表达较正常组织低,提示HSP70与外生殖器鳞癌有关。

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