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CD34、CD117和DOG1在胃肠道间质瘤鉴别诊断中的应用价值

Keywords: 胃肠道间质瘤,免疫组化,诊断

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Abstract:

目的探讨CD34、CD117和DOG1在胃肠道间质瘤(gastrointestinalstromaltumors,GIST)中的表达及其诊断价值。方法采用免疫组织化学SP法对2006年6月到2012年11月收治并手术治疗的GIST患者(66例)及非GIST患者(35例)的肿瘤标本进行CD34、CD117和DOG1蛋白表达检测。比较两组患者上述蛋白表达是否存在差别以及与GIST临床病理特征间的关系。结果GIST组患者CD34、CD117及DOG1阳性率分别为71.2%,93.9%和90.9%,非GIST组分别为9.1%,8.6%和11.4%,组间比较差别均有统计学意义(P0.05)。CD117、DOG1及两组联合检测判断GIST的敏感性分别为0.94(95%CI0.85~0.98)、0.91(95%CI0.81~0.97)和0.86(95%CI0.76~0.94);特异性分别为0.91(95%CI0.77~0.98)、0.89(95%CI0.73~0.97)和1.00(95%CI0.90~1.00),诊断的ROC曲线下面积分别为0.88,0.84和0.97。结论GIST患者CD34、CD117及DOG1表达与临床病理特征无显著相关性;联合检测CD117和DOG1可提高对GIST诊断的准确度。

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