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DNA甲基化与动脉粥样硬化的研究进展

, PP. 598-601

Keywords: 表观遗传学,DNA甲基化,动脉粥样硬化

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Abstract:

动脉粥样硬化是发生在大,中动脉,以粥样硬化斑块形成为病理特征的血管改变。以动脉粥样硬化为病理基础的多种疾病,如冠状动脉粥样硬化性心脏病、缺血性脑病、肾动脉狭窄、外周血管闭塞性病变等多种疾病,严重威胁人体健康。但动脉粥样硬化的发病机制尚未完全阐明。表观遗传学是指在DNA核酸序列不发生的改变的情况下,从染色质水平研究生物体如何对基因的表达实现调控1-2。其内容包括DNA甲基化,组蛋白修饰,RNA

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