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MMP-9、BAFF在原发性干燥综合征患者唇腺组织中 表达的相关研究

, PP. 424-4287

Keywords: 干燥综合征,唇腺疾病,免疫组织化学,基质金属蛋白酶-9,B细胞激活因子

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Abstract:

目的探讨基质金属蛋白酶-9(matrixmetalloproteinase-9,MMP-9)、B细胞激活因子(Bcellactivatingfactorofthetumornecrosisfactorfamily,BAFF)在原发性干燥综合征(PSS)发病过程中的作用和意义。方法采用免疫组化SP法检测50例PSS患者及30例正常对照组唇腺组织中MMP-9、BAFF的表达情况。结果50例PSS患者唇腺组织中MMP-9均阳性高表达,其表达的面积(14382.38±657.39)μm2、累积光密度(2705.46±868.76)均高于正常对照组(8445.10±361.84)μm2、(1114.26±570.82),且随着淋巴细胞浸润等级的增加,MMP-9表达增强,差异有统计学意义(P<0.05);50例PSS组患者唇腺组织中BAFF均阳性表达,其表达的面积(13586.72±1569.45)μm2、累积光密度(2073.57±850.73)均高于正常对照组(7116.83±338.19)μm2、(850.73±120.31),且随着淋巴细胞浸润等级的增加,BAFF表达增强(P<0.05);PSS组患者唇腺组织中MMP-9与BAFF的表达呈正相关(P<0.05)。结论MMP-9、BAFF的异常表达与原发性干燥综合征患者唇腺组织的破坏有关,二者参与了PSS的发病过程。

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