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急性冠脉综合征患者GRACE评分与N末端脑钠肽前体水平的相关性研究

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Keywords: N末端脑钠肽前体,全球急性冠状动脉事件注册,急性冠脉综合征,风险评估

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Abstract:

目的探讨急性冠脉综合征(ACS)患者N末端脑钠肽前体(NT-proBNP)与冠脉病变全球急性冠状动脉事件注册(GRACE)风险评分的相关性研究。方法选择137例ACS患者纳入ACS组,另选取经冠状动脉造影术后排除冠心病的老年患者89例作为对照组。入院24h内测定患者血浆NT-proBNP,1周内行冠脉动脉造影术。采用GRACE评分标准对ACS组患者进行危险分层,分为低危组(53例)、中危组(44例)和高危组(40例)3个亚组。分析ACS患者血浆NT-proBNP水平与GRACE评分的相关性及临床意义。结果与对照组相比,ACS患者NT-proBNP水平明显升高,差异有统计学意义(P<0.01);ACS患者GRACE评分均高于正常组(P<0.01)。血浆NT-proBNP水平与GRACE评分呈正相关关系(r=0.323,P<0.01))。结论NT-proBNP水平与GRACE评分呈正相关,可用于对ACS患者的危险分层。

References

[1]  Fox KA, Anderson FA Jr,Dabbous OH,et al.Intervention in acute coronary sydromes:do patients undergo intervention on the basis of their risk characteristics. The global registry of acute coronary events(GRACE)[J].Heart,2007,93(2):177-182.
[2]  Martins A, Ribeiro S, Goncalves P, et al. Role of central obesity in risk stratification after an acute coronary event: does central obesity and prognosis value to the global registry of acute coronary events(GRACE)risk score in patients with acute coronary syndrome[J]. Rev Port Cardiol,2013, 32(3):769-776.
[3]  Elbarouni B,Goodman SG,Yan RT,et al.Validation of the global registry of acute coronary event(GRACE)risk score for in-hospital mortality in patients with acute coronary syndrome in Canada[J].Am Heart J,2009,158(3):392-399.
[4]  Tang EW, Wong CK, Herbison P.Global registry of acute coronary events(GRACE)hospital discharge risk score accurately predicts long-term mortality post acute coronary syndrome[J]. Am Heart J,2007,153(1):29-35.
[5]  Arjamaa O.Physiology of natriuretic peptides: the volume overload hypothesis revisited[J]. World J Cardiol,2014, 6(1):4-7.
[6]  王爱萍,张焕轶,杨曙光,等.急性冠脉综合征患者血清氮末端脑钠尿肽原水平与冠脉病变程度的关系[J].心脏杂志,2011,23(5):629-632.
[7]  郭俊林,杨毅宁,马依彤,等.左室射血分数和全球急性冠状动脉事件注册评分对急性冠脉综合征患者不良心血管事件的预测价值[J]. 中华实用诊断与治疗杂志,2012,12(26):1174-1176.
[8]  Widera C,Pencina MJ,Meisner A,et al. Adjustment of the GRACE score by growth differentiation factor 15 enables a more accurate appreciation of risk in non-ST-elevation acute coronary syndrome[J].Eur Heart J,2012,33(9):1095-1104.
[9]  Hamano K1,Abe M,Komi R,et al.N-terminal fragment of pro?brain natriuretic peptide(NT-proBNP)for predicting silent myocardial ischaemia in type 2 diabetes mellitus independent of microalbuminuria[J].Diabetes Metab Res Rev,2010,26(7):534-539.
[10]  Gravning J,Smedsrud MK,Omland T,et al. Sensitive troponin assays and N-terminal pro-B-type natriuretic peptide in acute coronary syndrome: prediction of significant coronary lesions and long-term prognosis[J]. Am Heart J,2013, 165(5):716-724.
[11]  柯元南,陈纪林.不稳定性心绞痛和非ST段抬高心肌梗死诊断和治疗指南[J].中华心血管病杂志,2007,35(4):295-304.
[12]  中华医学会心血管病学分会,中华心血管病杂志编辑委员会.急性ST段抬高型心肌梗死诊断与治疗指南[J].中华心血管病杂志,2010,38(8):675-690.

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