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高迁移率族蛋白B-1在良性前列腺增生症中的表达与意义

, PP. 1189-1192

Keywords: 良性前列腺增生,高迁移率族蛋白B-1,炎症因子,炎症反应

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Abstract:

目的探讨晚期炎症因子高迁移率族蛋白B-1(highmobilitygroupbox1protein,HMGB1)在良性前列腺增生症(benignprostatichyperplasia,BPH)患者前列腺组织中的表达变化及其与BPH患者临床指标之间的相关性。方法收集40例行前列腺电切术的BPH患者前列腺组织标本,将其分为单纯BPH组和BPH伴慢性组织炎症组。HE染色法检测患者前列腺组织的病理情况,Westernblot法检测前列腺组织中HMGB1蛋白的表达,免疫组织化学检测HMGB1在前列腺组织中的分布;分析BPH患者前列腺组织HMGB1的表达与组织炎症、前列腺体积、患者年龄、血清前列腺特异性抗原(PSA)水平和前列腺症状(IPSS)评分等临床指标之间的相关性。结果40例BPH患者中52.5%(21例)伴有慢性组织炎症。与单纯BPH组相比,BPH伴慢性组织炎症组前列腺组织中HMGB1表达水平明显增高(P0.05)。BPH患者前列腺组织HMGB1蛋白表达水平与其前列腺体积呈正相关(P0.05)。结论晚期炎症因子HMGB1可能参与了BPH的发生过程。

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