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糖尿病视网膜病变血浆及眼内液VEGF水平的变化

Keywords: 糖尿病视网膜病变,血管内皮生长因子,血浆,房水,玻璃体

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Abstract:

目的探讨血管内皮生长因子(VEGF)在糖尿病视网膜病变(DR)发生发展过程中的作用。方法采用双抗体夹心ELISA法定量检测无糖尿病视网膜病变(NDR)组、非增殖期糖尿病视网膜病变(NPDR)组血浆中VEGF的含量,PDR病例组及对照组血浆、房水、玻璃体中VEGF含量。结果血浆NPDR组VEGF含量(88.17±25.8)pg?mL-1,明显高于NDR组(37.49±16.6)pg?mL-1和PDR组(63.12±16.25)pg?mL-1,PDR组VEGF含量高于NDR,以上三组中VEGF含量均高于正常对照组(14.39±10.48)pg?mL-1,各组比较差异有统计学意义(P房水>血浆(P<0.05)。结论VEGF在糖尿病视网膜病变新生血管的发生发展中发挥了重要作用。

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