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急性冠脉综合征患者血清C反应蛋白和脑钠素前体的变化及意义

Keywords: 急性冠脉综合征,高敏C反应蛋白,N末端脑钠素前体

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Abstract:

目的探讨急性冠脉综合征(ACS)患者血清高敏C反应蛋白(hs-CRP)和脑钠素N-末端前体(NTpro-BNP)的变化及意义。方法选择GRACE不同危险分层的急性冠脉综合征患者共86例(ACS组),对照组21例,检测两组血清CRP和NT-pro-BNP的变化,同时对ACS患者通过肌钙蛋白I(cTnI)等指标的分析将其分为低、中、高危三组。结果ACS组在性别、年龄、吸烟、糖尿病和高血压比例和对照组相比,差别无统计学意义(P>0.05);hsCRP在ACS组为(35.3±9.2)mg?L-1,ACS患者低危、中危和高危层组分别为(8.4±5.2)、(26.5±10.3)和(44.5±5.8)mg?L-1,对照组为(2.6±1.9)mg?L-1,ACS组及各危层组与对照组相比差异均有统计学意义(P均0.05)。结论血清hs-CRP与NT-pro-BNP在ACS及不同危险分层组变化显著,均可作为ACS危险分层的参考指标。

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