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不同年龄脓毒症患者血清脂联素与炎性因子相关性分析

, PP. 1028-1030

Keywords: 脓毒血症,脂联素,炎性因子

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Abstract:

目的研究不同年龄脓毒症患者血清脂联素水平与炎性因子的关系。方法诊断明确的脓毒血症患者201例作为研究对象,根据年龄分为青年组、中年组和老年组,检测各组患者血清中脂联素及IL-1、IL-6和TNF-α的水平,分析脂联素与炎性因子的关系。结果治疗前青年组血清脂联素水平高于中年组和老年组(P<0.05)、青年组血清IL-1、IL-6和TNF-α水平均低于中年组和老年组(P<0.05);血清脂联素水平与年龄呈负相关关系(r=-0.621,P<0.05);血清IL-1、IL-6和TNF-α水平与年龄呈明显正相关(rIL-1=0.654,rIL-6=0.328,rTNF-α=0.314,P<0.05);脂联素与三个炎性因子间均成明显负相关关系(rIL-1=-0.428,rIL-6=-0.746,rTNF-α=-0.396,P<0.05)。结论脓毒血症患者炎症反应随年龄增长而加强,其机制可能血清脂联素水平变化有关。

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