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血浆同型半胱氨酸和胆红素水平与颈动脉粥样硬化斑块关系研究

, PP. 987-989

Keywords: 缺血性脑卒中,同型半胱氨酸,总胆红素,动脉粥样硬化,颈动脉超声

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Abstract:

目的探讨缺血性脑卒中患者颈动脉粥样硬化(carotidatherosclerosis,CAS)斑块与血浆同型半胱氨酸(homocysteine,HCY)和胆红素(totalbilirubin,TBIL)水平之间的相关性。方法选取2013年1月~12月石嘴山市第一人民医院院神经内科缺血性脑卒中住院患者300例,分别测定血浆HCY和TBIL水平,并对颈部血管进行超声多普勒检测,根据颈动脉有无粥样硬化斑块分为斑块组(病例组,n=164例)和无斑块组(对照组,n=136例)。分析两组间血浆HCY和TBIL水平是否有差异;同时观察不同水平血浆HCY和TBIL与CAS斑块之间的关系。结果1病例组血浆HCY高于对照组,TBIL水平低于对照组,差别有统计学意义(P<0.05);2血浆HCY升高者CAS斑块检出率高于HCY正常者(P<0.05);3CAS斑块检出率在不同TBIL水平无统计学差异,但CAS斑块检出率随着TBIL水平的升高呈现逐渐减低趋势。结论血浆高HCY和低TBIL水平可能与缺血性脑卒中患者CAS斑块的形成有关。

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