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类风湿性关节炎患者血清血管内皮生长因子与炎性因子的表达水平及相关性分析

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Keywords: 类风湿性关节炎,血管内皮生长因子,C-反应蛋白,肿瘤坏死因子-α,白细胞介素-6

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Abstract:

目的探讨类风湿性关节炎(RA)患者血清血管内皮生长因子(VEGF)与炎性因子C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的表达水平及相关性分析。方法37例RA患者分为RA活动期组(21例)和RA缓解期组(16例),另采集20例健康体检者作为健康对照组。抽取所有受试者空腹静脉血离心取上清液,免疫比浊法测定CRP水平,酶联免疫吸附法测定VEGF、TNF-α和IL-6水平。结果RA缓解期组和RA活动期组TNF-α、IL-6、CRP和VEGF水平较健康对照组均显著升高(P均<0.05)。RA患者血清VEGF水平与TNF-α、IL-6、CRP均呈显著正相关(r分别为0.671、0.502、0.584,P均<0.05)。结论血清VEGF和TNF-α、IL-6、CRP水平高低能够反映RA患者病情活动变化,VEGF在类风湿性关节炎发病机制中可能和TNF-α、IL-6、CRP具有协同作用。

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