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MBL基因rs1800450与宁夏人群肺结核易感性研究

, PP. 889-893

Keywords: 甘露糖结合凝集素,肺结核,基因多态性,病例对照研究

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Abstract:

目的探讨甘露糖结合凝集素(mannose-bindinglectin,MBL)基因rs1800450与宁夏人群肺结核易感性的关系。方法采用病例-对照研究,用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法分析病例组(900例)及对照组(870例)MBLrs1800450基因型,并进行单因素分析和多因素非条件Logistic回归分析。结果rs1800450G、A等位基因频率和GG、GA、AA基因型频率在病例组和对照组中的分布均有显著性差异。在隐性模型中,携带AA基因型的个体发病危险性较携带GG和GA的个体有增高趋势(P<0.05,OR=1.985,95%CI为1.388~2.840)。结论携带MBL基因rs1800450AA基因型的宁夏个体患肺结核的风险增高。

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