全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

FGFR2基因rs2981582和rs1219648与乳腺癌相关性研究

Keywords: 乳腺癌,成纤维生长因子受体2,基因多态性,单体型

Full-Text   Cite this paper   Add to My Lib

Abstract:

目的探讨成纤维生长因子受体2(fibroblastgrowthfactorreceptor2,FGFR2)基因第2内含子rs2981582和rs1219648及其单体型与女性乳腺癌的相关性,分析各多态性位点与乳腺癌临床特征的相关性。方法采用病例-对照研究,PCR-RFLP方法检测203例乳腺癌患者和200例正常对照各位点基因型,分析各SNP及其单体型与乳腺癌的相关性、各位点的基因型分布与乳腺癌临床病理特征的相关性。结果(1)rs2981582基因TT型在病例组分布频率明显高于对照组(OR=1.831,95%CI=1.033~3.244,P=0.037),rs1219648基因型频率在两组中的分布差异无统计学意义(P>0.05)。(2)绝经后女性rs2981582基因TT型在病例组分布频率明显高于对照组(OR=2.659,95%CI=1.168~6.056,P=0.018);rs1219648基因TT型在病例组分布频率明显高于对照组(OR=3.051,95%CI=1.383~6.734,P=0.005)。两位点多态性与乳腺癌临床特征的相关性分析结果表明差异无统计学意义(P>0.05)。结论(1)FGFR2rs2981582可能与乳腺癌具有相关性;rs2981582和rs1219648可能与绝经后女性乳腺癌具有相关性。(2)FGFR2rs2981582和rs1219648与乳腺癌病人的发病年龄、有无淋巴转移、雌激素受体、孕激素受体无相关性。

References

[1]  Cha J,Lambert Q,Reuther G,et al.Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis[J].Mol Cancer Res,2008,6:435-445.?
[2]  Theodorou V,Kimm M,Boer M,et al.MMTV insertional mutagenesis identifies genes,gene families and pathways involved in mammary cancer[J].Nat Genet,2007,39:759-769.?
[3]  Moffa A,Tannheimer S,Ethier S,et al.Transforming potential of alternatively spliced variants of fibroblast growth factor receptor 2 in human mammary epithelial cells[J].Mol Cancer Res,2004,643-652.?
[4]  Luqmani Y,Graham M,Coombes C.Expression of basic fibroblast growth factor,FGFR1 and FGFR2 in normal and malignant human breast,and comparison with other normal tissues[J].Br J Cancer,1992,66:273-280.?
[5]  Hunter DJ,Kraft P,Jacobs KB,et al.A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer[J].Nat Genet,2007,39:870-874.?
[6]  Boyarskikh U,Zarubina N,Biltueva J,et al.Association of FGFR2 gene polymorphisms with the risk of breast cancer in population of West Siberia[ J].European Journal of Human Genetics,2009,17:1688-1691.?
[7]  Raskin L,Pinchev M,Arad C,et al.FGFR2 is a breast cancer susceptibility gene in Jewish and Arab Israeli populations[J].Cancer Epidemiol Biomarkers Prev,2008,17:1060-1065.?
[8]  Kawase T,Mastuo K,Suzuki T,et al.FGFR2 intronic polymorphisms interact with reproductive risk factors of breast cancer:Results of a case control study in Japan[J].Int J Cancer,2009,125:1946-1952.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133