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SYK和CA125在绿激光治疗非肌层浸润性膀胱肿瘤中的临床意义

, PP. 786-789

Keywords: 非肌层浸润性膀胱肿瘤,绿激光,脾酪氨酸激酶

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Abstract:

目的探讨脾酪氨酸激酶(Syk)甲基化和CA125表达在预测绿激光治疗非肌层浸润性膀胱肿瘤预后方面的意义,并揭示它们与肿瘤临床病理特征间的关系。方法对2006年1月至2011年7月经绿激光治疗的61例非肌层浸润性膀胱肿瘤患者进行临床疗效评估,并采用甲基化特异性聚合酶链反应(MSP)和逆转录-聚合酶链反应(RT-PCR)分别检测Syk甲基化状态和Syk表达,ELISA检测CA125表达情况,以分析Syk和CA125与肿瘤临床病理特征和预后间的关系。结果61例患者均可耐受手术,且肿瘤均成功切除,且均未出现术中膀胱穿孔和闭孔神经反射等严重并发症。术后随访24个月,其中复发6例(9.84%);有30例(49.2%)患者肿瘤无Syk表达,且其中有28例Syk启动子甲基化,同时有50例(82.0%)患者的CA125表达与瘤旁正常组织比较差异有统计学意义(P<0.05);Syk甲基化患者无复发生存率明显低于低甲基化患者(P<0.05);且发现Syk基因甲基化和CA125表达与肿瘤病理分期相关(P<0.05),但与病理分级、肿瘤大小及数目无关。结论绿激光治疗非肌层浸润性膀胱肿瘤安全有效,且发现Syk甲基化和CA125表达与肿瘤分期相关,并进一步证明了与患者临床预后的相关性,可作为非肌层浸润性膀胱肿瘤预后的预测指标。

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