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扩散加权成像对乳腺癌新辅助化疗效果评价的应用价值

Keywords: 乳腺癌,扩散加权成像,表观扩散系数,新辅助化疗

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Abstract:

目的探讨磁共振扩散加权成像(diffusionweightedimaging,DWI)在监测及评估乳腺癌新辅助化疗(neoadjuvantchemotherapy,NAC)效果中的应用价值。方法收集经穿刺活检证实并于手术前行NAC的乳腺癌患者30例,于化疗前与化疗结束后1周内分别行乳腺DWI成像扫描,测量病灶化疗前后表观扩散系数(apparentdiffusioncoefficient,ADC)值,依据RECIST1.1评价标准测量化疗前后病灶最大径线并分组。结果1化疗后有2例肿瘤消失,28例乳腺癌患者的ADC值在化疗前、后以及与对照组经比较差异有统计学意义(P0.05);3乳腺癌患者化疗前后ADC值变化率与靶肿瘤最大径线变化率呈正相关(r=0.731,P=0.021);4非完全缓解(partialresponse,PR)组和病变稳定(stabledisease,SD)组化疗前ADC值与最大径线变化率呈负相关(P<0.05)。结论DWI技术可作为一种评价新辅助化疗早期疗效的敏感、有效的方法。

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