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“三阴”型乳腺癌中Snail蛋白的表达及意义

Keywords: 乳腺癌,“三阴”型乳腺癌,Snail蛋白,复发转移,预后

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Abstract:

目的研究Snail蛋白在"三阴"型乳腺癌组织中的表达及与患者一般临床特征、病理参数的关系,探讨其对"三阴"型乳腺癌复发转移及预后的影响。方法采用免疫组化SP法检测40例"三阴"型乳腺癌组织及20例癌旁正常组织中Snail蛋白的表达水平,并分析其水平与临床病理参数、复发转移及预后的关系。结果1Snail蛋白在"三阴"型乳腺癌组织中阳性率高于癌旁正常组织(55.0%vs25.0%,P<0.05);2Snail蛋白的阳性表达愈高,淋巴结愈易转移、临床分期愈晚、复发转移率愈高、5年生存率愈低(P<0.05);3经Cox比例风险模型分析显示原发肿块大小、腋窝淋巴结转移数目、Snail蛋白的表达及临床分期为"三阴"型乳腺癌患者预后的独立危险因素。结论"三阴"型乳腺癌组织中Snail蛋白高表达,Snail蛋白可能参与了乳腺癌的发生发展,并且有可能作为判断"三阴"型乳腺癌复发、转移及预后的生物学指标。

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